Oligoribonucleotides Having 2'-Phosphate Groups
نویسندگان
چکیده
منابع مشابه
Association of 2'-5' oligoribonucleotides.
Oligoribonucleotides with 2'-5' linkages have been synthesized on solid support. UV melting and CD experiments indicate complementary strands associate to give complexes with melting temperatures 30 to 40 degrees C lower than for duplexes formed by 3'-5' oligoribonucleotides with the same sequence. UV melting and imino proton NMR spectra and NOEs for (2'-5') CGGCGCCG are consistent with formati...
متن کاملSite specific labelling of sugar residues in oligoribonucleotides: reactions of aliphatic isocyanates with 2' amino groups.
Considerable effort has been directed towards studying the structure and function of nucleic acids and several approaches rely on the attachment of reporter groups or reactive functional groups to nucleic acids. We report here the selective modification of 2-amino groups in oligoribonucleotides, through their reaction with aliphatic isocyanates, to give the corresponding 2'-urea derivatives in ...
متن کاملIncorporation of 2'-amido-nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates
The functionalisation of oligodeoxynucleotides and oligoribonucleotides by incorporation of 2'-amido-2'-deoxyribonucleosides, possibly containing a reporter group via the 2'-amido bond, was examined. Therefore 2'-acetamido-ribonucleosides containing a small methyl group at the 2'-amido bond were synthesized as model compounds. In order to evaluate the influence of this 2'-modification on the hy...
متن کاملProbability of having $n^{th}$-roots and n-centrality of two classes of groups
In this paper, we consider the finitely 2-generated groups $K(s,l)$ and $G_m$ as follows:$$K(s,l)=langle a,b|ab^s=b^la, ba^s=a^lbrangle,\G_m=langle a,b|a^m=b^m=1, {[a,b]}^a=[a,b], {[a,b]}^b=[a,b]rangle$$ and find the explicit formulas for the probability of having nth-roots for them. Also, we investigate integers n for which, these groups are n-central.
متن کاملStructural Comparison of Oligoribonucleotides and Their 2 ’ - Deoxy - 2 ’ - fluoro Analogs by Heteronuclear NMR spectroscopy
1 -(2’-Deoxy-2’-fluororibofuranosyl)pyrimidines were synthesized and incorporated into an RNA oligonucleotide to give ~-r[~G~(U,U,(;G)G~GJ-3‘ (Cf: short form of Cdl.f2. = 2’-deoxy-2‘-fluorocytidine; U,: short form of U,,.,,. = 2’-deoxy-2’-fluorouridine). The oligomer was investigated by means of UV, CD, and NMR spectroscopy to address the question of how F-labels can substitute ”C-labels in the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kobunshi
سال: 1993
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.42.109